World’s first baby born via womb transplant from dead donor

Tuesday, 11 December 2018 00:31 - - {{hitsCtrl.values.hits}}

This handout picture released by the Hospital das Clinicas of the Faculty of Medicine of the University of Sao Paulo (FMUSP) shows medical staff holding a baby born from a mother who had the first-ever uterus transplant from a dead donor in Sao Paulo, Brazil on 15 December 2017. - Doctors in Brazil who carried out the first-ever uterus transplant from a dead donor which resulted in the birth of a baby girl a year ago say they have two more women waiting to undergo the same procedure. (Photo by HO / Hospital das Clinicas da FMUSP / AFP)

LONDON (Reuters) - A woman in Brazil who received a womb transplant from a deceased donor has given birth to a baby girl in the first successful case of its kind, doctors reported.

The case, published in The Lancet medical journal, involved connecting veins from the donor uterus with the recipient’s veins as well as linking arteries, ligaments and vaginal canals.

It comes after 10 previously known cases of uterus transplants from deceased donors - in the United States, the Czech Republic and Turkey - failed to produce a live birth.

The girl born in the Brazilian case was delivered via caesarean section at 35 weeks and three days, and weighed 2,550 g (nearly 6 lbs), the case study said.

Dani Ejzenberg, a doctor at Brazil’s Sao Paulo University Hospital who led the research, said the transplant - carried out in September 2016 when the recipient was 32 - shows the technique is feasible and could offer women with uterine infertility access to a larger pool of potential donors.

The current norm for receiving a womb transplant is that the organ would come from a live family member willing to donate it.

“The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population,” Ejzenberg said in a statement about the results.

She added however that the outcomes and effects of womb donations from live and deceased donors have yet to be compared, and that the technique could still be refined and optimised.

The first baby born after a live donor womb transplant was in Sweden in 2013. Scientists have so far reported a total of 39 procedures of this kind, resulting in 11 live births.

Experts estimate that infertility affects around 10 to 15% of couples of reproductive age worldwide. From this group, around one in 500 women have uterine problems.

Before uterus transplants became possible, the only options to have a child were adoption or surrogacy.

In the Brazilian case, the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome. The donor was 45 and died of a stroke.

Five months after the transplant, Ejzenberg’s team wrote, the uterus showed no signs of rejection, ultrasound scans were normal, and the recipient was having regular menstruation. The woman’s previously fertilised and frozen eggs were implanted after seven months, and 10 days later she was confirmed pregnant.

At seven months and 20 days - when the case study report was submitted to The Lancet - the baby girl was continuing to breastfeed and weighed 7.2 kg (16 lb).