Home / Healthcare/ Identification of protective antibodies may be key to effective malaria vaccine

Identification of protective antibodies may be key to effective malaria vaccine


Comments / {{hitsCtrl.values.hits}} Views / Thursday, 20 June 2019 00:00

Facebook

 


An Oxford-led study has identified the antibodies that may hold the key to creating the first effective vaccine against malaria infection in the blood. 

Researchers from the University of Oxford, along with partners from five institutions around the world, have identified the human antibodies that prevent the malaria parasite from entering blood cells, which may be key to creating a highly effective malaria vaccination. The results of the study were published today in the journal Cell.

“Following an infectious mosquito bite, the malaria parasite goes first to the human liver, and then moves into the blood. Here it replicates 10-fold every 48 hours inside red blood cells – it is this blood-stage of the infection that leads to illness and can be fatal,” explains study author University of Oxford Nuffield Department of Medicine Professor of Vaccinology and Translational Medicine Simon Draper.  “The malaria parasite has a protein called RH5, which must bind to a human protein on red blood cells called basigin in order to infect them. In this study, we were able to demonstrate which human antibodies effectively block RH5 from binding with basigin, thus preventing the parasite from spreading through the blood.”

The study was done as part of a clinical trial in Oxford of the first vaccine that targets the RH5 malaria protein. Until now, however, it was not clearly understood which specific antibodies could be generated by vaccination of a human volunteer and would effectively prevent RH5 from binding to red blood cells.  “When someone is vaccinated, they make many different types of antibodies against the same RH5 target,” explains co-author and researcher Dr. Daniel Alanine. “This study is key to understanding which specific antibodies are actually effective against malaria, and which are not.”

Another key finding of the study is the identification of an exciting new antibody, which works by slowing down the speed in which RH5 binds to red blood cells. “The parasite can still invade, but this antibody slows down the invasion,” says study co-author University of Oxford Department of Biochemistry Professor of Molecular Parasitology Matthew Higgins. 

“This gives the antibodies that do block RH5 more time to act, helping them become more effective. This is an exciting finding because it shows that antibodies which do not prevent the parasite from getting into red blood cells might still be useful, by making the protective antibodies more potent.” There remains an urgent need to develop an effective malaria vaccine. Despite the increasing use of bed nets, insecticides and drugs in malaria-endemic regions, malaria still kills approximately 430,000 people each year. Scientists have yet been unsuccessful at creating a vaccine that works against the malaria parasite in the blood. The current vaccine based on RH5 has so far shown real promise, and continues to be trialled in the UK and Africa.

“We know the key to stopping malaria is a strong immune response, and so every antibody counts,” says Draper. “What we must do next is use these findings to develop an improved RH5 vaccine that induces more of the effective antibodies and less of the non-effective ones – this will ultimately make a better vaccine, and hopefully lead to an effective means of preventing malaria.”

This work was done in collaboration with researchers at the Burnet Institute (Australia), Centre for Global Infectious Disease Research at the Seattle Children’s Research Institute (USA), Laboratory of Malaria and Vector Research (USA), Cell Surface Signalling Laboratory at the Wellcome Trust Sanger Institute (Cambridge), and ExpreS2ion Biotechnologies (Denmark).

Oxford University has been placed number one in the Times Higher Education World University Rankings for the third year running, and at the heart of this success is its ground-breaking research and innovation. Oxford is world-famous for research excellence and home to some of the most talented people from across the globe. Its work helps the lives of millions, solving real-world problems through a huge network of partnerships and collaborations. The breadth and interdisciplinary nature of our research sparks imaginative and inventive insights and solutions.

 


Share This Article

Facebook Twitter


DISCLAIMER:

1. All comments will be moderated by the Daily FT Web Editor.

2. Comments that are abusive, obscene, incendiary, defamatory or irrelevant will not be published.

3. We may remove hyperlinks within comments.

4. Kindly use a genuine email ID and provide your name.

5. Spamming the comments section under different user names may result in being blacklisted.

COMMENTS

Today's Columnists

“Sri Lanka’s future lies in producing exportable manufactured goods”: Dr. Howard Nicholas

Monday, 22 July 2019

Drawing lessons from Vietnam’s experiences The Sri Lanka-born economist attached to The Hague based Institute of Social Studies – Dr. Howard Nicholas – addressing a packed audience consisting of the alumni of the Postgraduate Institute of Manag


We should sell our water

Monday, 22 July 2019

When you read the title of this article, you will probably feel disgusted with me as selling our water has been a controversial topic since a long time ago. By the way, I am talking about virtual water trade and you would be surprised to know that we


A voice of compassion amid howls of zealotry

Monday, 22 July 2019

The unrestrained freedom extended by the current regime to a bunch of saffron-clad street vendors of Sinhala Buddhist zealotry is pushing Sri Lanka once again into a cauldron of ethnic and religious convulsion. The nationwide spread and virulence of


Roger Beteille: The man who reinvented the commercial airliner

Monday, 22 July 2019

The visionary engineer, pilot and manager who led Airbus to some its most significant decisions, passed away last month. Beteille, who was the head of French aircraft manufacturer Sud Aviation’s flight testing section, was made technical director


Columnists More